During week 1 (and sometimes week 2) your body is transitioning to this whole new metabolic state, and there may be some initial side effects. These are collectively known as the "keto flu". The good thing is that if you don't take them for granted and think you're "superman" and that your body will be different, you can easily prevent these symptoms.
Paleo and keto can overlap, though there are some major differences in the core of each way of eating. The Paleo diet focuses on whole, natural foods that would have been available as food to our paleolithic ancestors. If it could have been hunted or foraged, then it would have been eaten. Some people on a Paleo plan also focus on what would have been growing in season, and in a certain region of the world for their genetic ancestors. Carbs are overall allowed in a Paleo plan, but they would come from whole foods like potatoes, sweet potatoes, fruits, honey, and other unprocessed sources.
In a state of ketosis, your body breaks fat down in the liver and converts it into ketones to be used for energy. Fat doesn't generate an insulin response, so insulin levels remain stable. This makes it much harder to store excess fat, and easier to tap into body fat stores for energy. Not only will this allow you to maintain your weight, but it will greatly encourage weight loss.
Following a diet that drastically restricts carbohydrates requires carefully monitoring your food choices to ensure you are meeting your nutritional needs. Working together with a registered dietitian can make sure you follow this diet in a healthy manner without increasing your risk for complications or negative side effects. You can find a registered dietitian at EatRight.org.
A related clinical diet for drug-resistant epilepsy is called the medium-chain triglyceride ketogenic diet, in which MCT oil is extensively used because it's more ketogenic than long-chain triglycerides. (13a) Another dietary therapy for epilepsy called Low Glycemic Index Treatment (LGIT) was developed in 2002 as an alternative to the ketogenic diet. LGIT monitors the total amount of carbohydrates consumed daily, and focuses on carbohydrates that have a low glycemic index.) (13b)
I've always heard that the brain functions well on ketones. Gluconeogenisis typically reduces ketosis, though as well? This is the first time I've heard anyone say the brain can't use anything but glucose. I know there's *preferred* sources of fuel over others, but I was also fairly certain other sources were fine.. or humans might be in a bit of trouble.
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